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Home Antibody All anti-FAS antibodies

Anti-FAS Antibody EPR5700

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310480
  • Rabbit Monoclonal antibody against CD95 / Fas
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424961) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for FAS (NM_000043)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA recombinant protein fragment corresponding to residues in human CD95 / Fas was used as an immunogen.
Clone NameEPR5700 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC/IF: 1:250 - 1:500; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens Fas cell surface death receptor (FAS), transcript variant 1
Alternative NameALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Database LinkNP_000034
FunctionCD95 / Fas is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and it has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of CD95 / Fas with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and it is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells (1).
Related Pathway
Adipogenesis
Apoptosis
Cytokine-cytokine receptor interaction
MAPK signaling pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD95 antibody [EPR5700 ]; All lanes : Anti-CD95 antibody [EPR5700 ] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HT-1080 cell lysate.Lane 3 : Raji cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD95 antibody [EPR5700 ]; Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling CD95 with TA310480 antibody at a dilution of 1/250.

 

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