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Home Antibody All anti-FANCA antibodies

Anti-FANCA Antibody

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SKU Description Amount Price Availability*  
TA319302 Rabbit polyclonal anti-FANCA antibody 100ug $325 3-7 Days
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WB(2)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 995-1009 of human FANCA protein.
Clone Name IsotypeIgG
Species Reactivityhuman, chimpanzee Concentration2.2 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:15,000 - 1:60,000, WB: 1:500 - 1:3,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.  The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia

Reference Data

Target NameHomo sapiens Fanconi anemia, complementation group A (FANCA), transcript variant 1
Alternative NameFA; FA-H; FA1; FAA; FACA; FAH; FANCH
Database LinkNP_000126
Entrez Gene 2175 Human
Function
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot using affinity purified anti-FANCA antibody shows detection of FANCA only in FANCA transfected GM6914 cell lysates.  No staining is seen in lysates prepared from FANCA (-/-) cells in the absence of FANCA transfection. Modified from Smogorzewska et al (2007) Cell 129, 289-301.
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WB using Anti-FANCA antibody shows detection of a band at ~133 kDa (arrowhead) corresponding to FANCA in HeLa whole cell lysates. The identity of the lower molecular weight bands is unknown but may represent breakdown products. Primary antibody was used at a 1:1,500 dilution. Molecular weight estimation was made by comparison to prestained MW markers indicated at left (700 nm channel, red).
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