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Home Antibody All anti-FAIM3 antibodies

Anti-FAIM3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306040
  • Rabbit Polyclonal Toso Antibody
100ug 325 3-7 Days
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WB(1)
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Also for FAIM3 (NM_001142472)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenToso antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Fas apoptotic inhibitory molecule 3 (FAIM3), transcript variant 2
Alternative NameTOSO; OTTHUMP00000034619; regulator of Fas-induced apoptosis; Fas apoptotic inhibitory molecule 3
Database LinkNP_001135944
FunctionApoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.
Related Pathway

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WB Image
Western blot analysis of Toso in human lung tissue lysate with Toso antibody at 1 µg/ml in either the (A) presence, or (B) absence of blocking peptide.

 

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