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Anti-FADD Antibody EP887Y
Also for FADD (NM_003824)
|A synthetic peptide corresponding to residues near the N-term of human FADD was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500; IHC: 1:100 - 250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Rat
|Homo sapiens Fas (TNFRSF6)-associated via death domain (FADD)|
|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq]. |
Toll-like receptor signaling pathway
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Western blot - FADD antibody [EP887Y]; Anti-FADD antibody [EP887Y] at 1/500 dilution + Jurkat cell lysate at 10 µg.Secondary.HRP-labelled goat anti-rabbit.Predicted band size : 23 kDa.
Immunohistochemistry (Paraffin-embedded sections) - FADD antibody [EP887Y]; Immunohistochemical analysis of paraffin-embedded human lung tissue using ab52935 at a dilution of 1/100-1/250.