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Home Antibody All anti-FADD antibodies

Anti-FADD Antibody EP887Y

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SKU Description Amount Price Availability*  
TA303862
  • Rabbit monoclonal antibody against FADD (N-term)(EP887Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401265) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-term of human FADD was used as immunogen.
Clone NameEP887Y IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:100 - 250
Predicted MW Explanation 23 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
Entrez Gene 14082 Mouse
FunctionThe protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq].
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - FADD antibody [EP887Y]; Anti-FADD antibody [EP887Y] at 1/500 dilution + Jurkat cell lysate at 10 ug.Secondary.HRP-labelled goat anti-rabbit.Predicted band size : 23 kDa.
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Immunohistochemistry (Paraffin-embedded sections) - FADD antibody [EP887Y]; Immunohistochemical analysis of paraffin-embedded human lung tissue using TA303862 at a dilution of 1/100-1/250.
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