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Home Antibody All anti-F13A1 antibodies

Anti-F13A1 Antibody EP3371

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307747
  • Rabbit monoclonal antibody against Factor XIII A (clone EP3371 )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400044) , 20ug
100ul 325 In Stock
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WB(1)
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Also for F13A1 (NM_000129)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Factor XIII A was used as an immunogen.
Clone NameEP3371 IsotypeTissue culture supernatant
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; IP: 1:20
BufferDoes not react with Mouse. Is unsuitable for IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens coagulation factor XIII, A1 polypeptide (F13A1)
Alternative NameF13A
Database LinkNP_000120
FunctionFactor XIII (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. It circulates in blood as a tetramer consisting of two “A” and two “B” subunits (1, 2). The amino acid sequence of the enzymatically active subunit, Factor XIII A, is unique and does not exhibit internal homology, but its active center is similar to that of the thiol proteases. Factor XIII A is activated by thrombin and calcium ion to a transglutaminase that catalyzes the cross linking of fibrin molecules, forming intermolecular isopeptide bonds, thus stabilizing blood clots (3, 4). In two diseases that share some histological resemblance (Lymphocyte-poor graft-versus-host-reaction and toxic epidermal necrolysis), Factor-XIII A-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment. Factor-XIII A-positive dendrocytes thus are reported to possibly play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction (5).
Related Pathway
Hemostasis

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WB Image
Western blot - Factor XIIIa antibody [EP3371]; All lanes : Anti-Factor XIIIa antibody [EP3371] at 1/2000 dilution.Lane 1 : Human placenta lysate.Lane 2 : PMBC lysate.Lane 3 : Rat platelets lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 83 kDa.Observed band size : 83 kDa.Additional bands at : 65 kDa,75 kDa. We are unsure as to the identity of these extra bands.

 

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