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Home Antibody All anti-F11 antibodies

Anti-F11 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308541 Rabbit Polyclonal antibody to Factor XI (coagulation factor XI) 100ul $325 3-7 Days
LC400043 F11 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 312 of Factor XI (Uniprot ID#P03951)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Dog, Rabbit) Concentration0.55mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 70kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (83%), Rabbit (82%)

Reference Data

Target NameHomo sapiens coagulation factor XI (F11)
Alternative NameFXI
Database LinkNP_000119
Entrez Gene 2160 Human
Entrez Gene 475623 Dog
FunctionThis gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]
Related PathwaySecreted ProteinProteaseDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308541 diluted at 1:1000
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Immunohistochemical analysis of paraffin-embedded Breast ca, using Factor XI(TA308541) antibody at 1:250 dilution.
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