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Anti-EWSR1 Antibody EPR4647
Also for EWSR1 (NM_005243)
|A synthetic peptide corresponding to residues in human EWSR1/EWS was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IHC-P: 1:250 - 1:500; ICC: 1:500 - 1:1000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens EWS RNA-binding protein 1 (EWSR1), transcript variant 2|
|EWSR1 / EWS is a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this protein and various proteins that are transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in EWSR1 / EWS are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors (1).|
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Western blot - Anti-EWSR1 antibody [EPR4647]; All lanes : Anti-EWSR1 antibody [EPR4647] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : F9 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 68 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EWSR1 antibody [EPR4647]; Immunohistochemical analysis of paraffin-embedded Human colon tissue labelling EWSR1 with ab133288 at 1/250 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EWSR1 antibody [EPR4647]; Immunohistochemical analysis of paraffin-embedded Human colonic adenocarcinoma tissue labelling EWSR1 with ab133288 at 1/250 dilution.