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Home Antibody All anti-ESR1 antibodies

Anti-ESR1 Antibody EPR703(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307748
  • Rabbit monoclonal antibody against ER alpha (clone EPR703(2) )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400046) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
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Also for ESR1 (NM_000125)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human ERalpha was used as immunogen.
Clone NameEPR703(2) IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 - 1:1000; IHC-P: 1:500 - 1:1000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens estrogen receptor 1 (ESR1), transcript variant 1
Alternative NameER; Era; ESR; ESRA; ESTRR; NR3A1
Database LinkNP_000116
FunctionEstrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy (3).
Related Pathway
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Estrogen Receptor alpha antibody [EPR703(2)]; Anti-Estrogen Receptor alpha antibody [EPR703(2)] at 1/1000 dilution + MCF-7 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 68 kDa.Observed band size : 66 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Estrogen Receptor alpha antibody [EPR703(2)]; TA307748, at 1/500 dilution, staining Estrogen Receptor alpha in paraffin-embedded human breast carcinoma tissue by Immunohistochemistry.

 

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