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Anti-ESR1 Antibody EPR703(2)
Also for ESR1 (NM_000125)
|A synthetic peptide corresponding to residues on the C-terminus of human ERalpha was used as immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1:1000; IHC-P: 1:500 - 1:1000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1|
|ER; Era; ESR; ESRA; ESTRR; NR3A1|
|Estrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy (3). |
TGF Beta Signaling Pathway
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Western blot - Estrogen Receptor alpha antibody [EPR703(2)]; Anti-Estrogen Receptor alpha antibody [EPR703(2)] at 1/1000 dilution + MCF-7 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 68 kDa.Observed band size : 66 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Estrogen Receptor alpha antibody [EPR703(2)]; TA307748, at 1/500 dilution, staining Estrogen Receptor alpha in paraffin-embedded human breast carcinoma tissue by Immunohistochemistry.