Home All anti-ERBB3 antibodies
Anti-ERBB3 Phospho Antibody EPR2325
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ERBB3 (NM_001005915)
|A phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of human HER3/ErbB3 was used as an immunogen. The antibody only detects HER3/ErbB3 phosphorylated on Tyrosine 1289.|
||WB: 1:2500 -5000; ICC: 1:100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s|
|c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3|
|This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq]. |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on SKBR3 cell lysate using anti-Phospho-HER3/ErbB3 (pY1289) RabMAb (TA303500), 1:5000 dilution. Cells were either (A) untreated (B) treated with Neuregulin
Immunofluorescent staining of MCF7 cells using phospho-specific anti-HER3/ErbB3 (pY1289) RabMAb (TA303500).