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Home Antibody All anti-EIF2AK2 antibodies

Anti-EIF2AK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306357
  • Rabbit Polyclonal PKR Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC427650) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for EIF2AK2 (NM_001135651)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenPKR antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human PKR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 2
Alternative NameEIF2AK1; PKR; PRKR
Database LinkNP_001129123
FunctionThe interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Related Pathway

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WB Image
Western blot analysis of PKR in Caco-2 whole cell lysate with PKR antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of PKR in rat lung tissue with PKR antibody at 5 ug/ml.

 

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