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Anti-EGFR Antibody E114

WB(1)

IHC(1)

IF(1)

Gene Name Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3 Synonyms: ERBB; ERBB1; HER1; mENA; PIG61 Immunogen A synthetic peptide corresponding to residues near C-terminus of human EGF receptor was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name E114 Isotype Rabbit IgG Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC, IF Suggested Dilutions WB: 1:5,000; IHC: 1:10-25; ICC: 1:10; IP: 1:10 Background The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq]. Related Pathway Adherens junction Cytokine-cytokine receptor interaction Delta-Notch Signaling Pathway EGFR1 Signaling Pathway Focal Adhesion MAPK signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 3 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • EGFR - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • EGFR - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Egfr - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • EGFR - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Egfr - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3 as transfection-ready DNA • Extra Cellular Domain Clone of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3, Signal peptide (1-24) plus EC domain (25-405) • GFP-tagged ORF clone of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3 as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)