OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-Dlg4 antibodies

Anti-Dlg4 Antibody 7E3

div

Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326528 Mouse Monoclonal Anti-PSD95 Antibody 100µg $325 3-7 Days
Add to Shopping Cart
spacer
WB(1)
IF(2)
Write Review & Get Rewarded
X

Write a review and get rewarded!

Review this antibody and earn an OriGene coupon or Amazon giftcard

Follow these easy steps to reward yourself:

  1. Sign in to your account, or register for a new account;
  2. Write a review;
  3. Receive a coupon or giftcard once your review is accepted.

Click the button to start writing a review


OriGene Data

ImmunogenRecombinant rat PSD-95
Clone Name7E3 IsotypeIgG2a
Species ReactivityMouse, Rat, Bovine Concentration1mg/mL
Guaranteed Application *WB, IF Suggested Dilutions1ug/ml was sufficient for detection of PSD-95 on 20ug rat brain tissue extract.
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects a ~100kDa protein corresponding to the molecular mass of PSD-95 on SDS PAGE immunoblots. Additional cross-reactive bands are detected at ~80kDa and ~50kDa in rat and mouse samples.

Reference Data

Target NameRattus norvegicus discs, large homolog 4 (Drosophila) (Dlg4)
Alternative NameDlgh4; PSD95; Sap90
Database LinkNP_062567
Entrez Gene 13385 Mouse
Entrez Gene 29495 Rat
FunctionPostsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of PSD95 in rat membrane using a 1:1000 dilution of the antibody
spacer

IF Image
ICC localization of Psd95 in rat neocortex.
spacer

IF Image
PSD95 visualized using the antibody
spacer

 

spacer
Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title

Notice to Non-US Customers

ExclaimationWeb price and delivery time are for direct sales only.

Non-US customers are encouraged to contact our dedicated distributor network for quotes and streamlined ordering/delivery support.

Acknowledge