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Home Antibody All anti-Dffb antibodies

Anti-Dffb Antibody

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SKU Description Amount Price Availability*  
TA305970
  • Rabbit Polyclonal CAD Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenCAD antibody was raised against a peptide corresponding to 17 amino acids near the center of murine CAD .
Clone Name IsotypeIgG
Species ReactivityMouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus DNA fragmentation factor, beta subunit (Dffb)
Alternative Name40kDa; 5730477D02Rik; CAD; CPAN; DFF40; Didff
Database LinkNP_031885
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
Related Pathway

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WB Image
Western blot analysis of CAD in mouse kidney tissue lysate with CAD antibody at 2 ug/ml.
IHC Image
Immunohistochemistry of CAD in mouse kidney tissue with CAD antibody at 2 ug/ml.

 

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