Home Antibody All anti-DSC2 antibodies
Anti-DSC2 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for DSC2 (NM_024422)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
|Human , Dog , Rat , Monkey
|| WB 1:5000~20000,ELISA 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a|
|ARVD11; CDHF2; DG2; DGII/III; DSC3|
Entrez Gene 1824 Human
Entrez Gene 291760 Rat
Entrez Gene 712805 Monkey
Entrez Gene 403860 Dog
|The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.|
|Transmembrane Arrhythmogenic right ventricular cardiomyopathy (ARVC)|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DSC2 (RC209218, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DSC2.
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-DSC2 polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).