CRMP-2 is a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. CRMP-2 promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This protein has been implicated in multiple neurological disorders, and hyperphosphorylation of CRMP-2 may play a key role in the development of Alzheimer's disease (1).
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