Home Antibody All anti-DNAJB1 antibodies
Anti-DNAJB1 Antibody N/A
Also for DNAJB1 (NM_006145)
|Recombinant purified human hsp40|
|Human, Mouse, Rat, African Green Monkey
|Detects an ~40kDa protein corresponding to the molecular mass of Hsp40 on SDS PAGE immunoblots. Also detects recombinant Hsp40.
|Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1), transcript variant 1|
|Hdj1; Hsp40; HSPF1; RSPH16B; Sis1|
Entrez Gene 3337 Human
Entrez Gene 81489 Mouse
Entrez Gene 361384 Rat
|DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s. Hsp40, also known as HDJ1 , is a basic mammalian 40kDa heat shock protein which is not only homologous to the bacterial heat shock protein (DnaJ), but also yeast DnaJ-related proteins such as SCJ1, Sec63/Npl1, YDJ1 and SIS1 . Hsp 40 is inducible by stress including heat after which is moves from the cytoplasm to the nucleus and nucleoli; an intracellular pattern similar to Hsc70/Hsp70, the mammalian homologues of the bacterial heat shock protein, DnaK .|
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Western blot analysis of Hsp40 in HeLa cell lysates using a 1:1000 dilution of the antibody