Home Antibody All anti-DLX4 antibodies
Also for DLX4 (NM_138281)
|A synthetic peptide made specifically to the human BP1 protein sequence (between residues 1-60).There is no homology with the peptide sequences used for immunogen of this antibody and the DLX4 or DLX7 proteins.|
||WB: 1: 1000, IHC: 1:50-1: 100
|Tris-citrate/phosphate, pH 7-8, 0.1% sodium Azide|
|Immunogen affinity purified
|Homo sapiens distal-less homeobox 4 (DLX4), transcript variant 1|
|BP1; DLX7; DLX8; DLX9|
Entrez Gene 1748 Human
|DLX (Distal-less) genes are essential for early development. BP1 (beta protein 1) is a homeodomain-containing isoform of DLX4. Strong BP1 expression is seen in placenta and kidney tissue, with no expression found in any other tissue (1). This protein has been shown to be activated in 80% of invasive ductal breast tumors and is associated with breast cancer progression ( 2, 3). It is also expressed in the bone marrows of 63% of acute myeloid leukemia (AML) patients (4). In addition, BP1 plays a role in globin gene regulation by repressing the beta- globin gene (1). |
|Transcription Factors |
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Detection of MDA-MB-231 cell lysates
Immunoprecipitation: Antibody diluted 1:5,000 2. BP1-specific band after immunoprecipitation of 850 ug of cell extract using anti-BP1 (NB100-481) antibody diluted 1:1,000 3. Negative control for IP in lane 2: cell extract incubated with 50ul of Protein A/G beads.
Immunohistochemistry - Top Panel: BP1 antibody detected in breast cancer cells. Bottom Panel: Staining of normal breast cancer cells.