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Anti-DLG4 Antibody S28-43
Also for DLG4 (NM_001365)
|Fusion protein amino acids 77-200 of human PSD95/SAP90 |
|Mouse, Rat, Human
|PBS pH7.4, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Homo sapiens discs, large homolog 4 (Drosophila) (DLG4), transcript variant 1|
|PSD95; SAP-90; SAP90|
|Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .|
Wnt Signaling Pathway
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Immunolabelling of PSD95 using a dilution of the antibody
IF of PSD95 in cultures of dissociated hippocampal neurons. Cultures were grown and labeled with antibodies against the indicated proteins. A neuron double stained for PSD95.