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Home All anti-Dffa antibodies
Anti-Dffa Antibody
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
OriGene Data
| ICAD antibody was raised against a peptide corresponding to amino acids near the amino terminus of mouse ICAD . |
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IgG |
| Mouse |
1ug/ul |
| WB, IHC |
WB: 0.5 - 1 ug/ml |
| PBS containing 0.02% sodium azide. |
| Affinity chromatography purified via peptide column (Protein A or G Sepharose) |
Reference Data
| Mus musculus DNA fragmentation factor, alpha subunit (cDNA clone MGC:68183 IMAGE:5367607), complete cds |
| ICAD, Dff45, ICAD-L, ICAD-S, DFF35 |
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| Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which is cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death. |
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* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis of ICAD in mouse lung tissue lysate with ICAD antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of ICAD in murine lung tissue with ICAD antibody at 2 ug/ml.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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