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Home Antibody All anti-DFFA antibodies

Anti-DFFA Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305956 Rabbit Polyclonal DFF45 Antibody 100ug $325 3-7 Days
LC418008 DFFA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenDFF45 antibody was raised against a peptide corresponding to amino acids 313 to 331 of human DFF45.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 1 ug/mL, ICC: 5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Alternative NameDFF-45; DFF1; ICAD
Database LinkNP_004392
Entrez Gene 1676 Human
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kDa DNA fragmentation factor (DFF45) was identified recently which was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD (2,3). Upon cleavage of DFF45/ICAD, a caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.
Related Pathway Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DFF45 in HeLa (H), Jurkat (J), A431 (A), and K562 (K) whole cell lysate with DFF45 antibody at 1:1000 dilution.

IF Image
Immunocytochemistry of DFF45 in HeLa cells with DFF45 antibody at 5 ug/mL.


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