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Anti-DDX60 Antibody Polyclonal
Also for DDX60 (NM_017631)
|DDX60 antibody was raised against a 17 amino acid synthetic peptide near the center of human DDX60.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IF: 20 ug/ml
|DDX60 Antibody is supplied in PBS containing 0.02% sodium azide.|
|DDX60 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60)|
|DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.|
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Western blot analysis of DDX60 in A20 cell lysate with DDX60 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of DDX60 in A20 cells with DDX60 antibody at 20 ug/mL.