Home Antibody All anti-DDX58 antibodies
Also for DDX58 (NM_014314)
|RIG-1 antibody was raised against human GST-tagged RIG-1 protein.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)|
|RIG-I; RIGI; RLR-1|
Entrez Gene 23586 Human
Entrez Gene 230073 Mouse
Entrez Gene 297989 Rat
|The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.|
| RIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of RIG-1 in C2C12 cell lysate with RIG-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of RIG-1 in human heart tissue with RIG-1 antibody at 5 ug/ml.