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Home Antibody All anti-DDX58 antibodies

Anti-DDX58 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306359
  • Rabbit Polyclonal RIG-1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC415370) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for DDX58 (NM_014314)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRIG-1 antibody was raised against human GST-tagged RIG-1 protein.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)
Alternative NameRIG-I; RIGI; RLR-1
Database LinkNP_055129
FunctionThe innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Related Pathway

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WB Image
Western blot analysis of RIG-1 in C2C12 cell lysate with RIG-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of RIG-1 in human heart tissue with RIG-1 antibody at 5 ug/ml.

 

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