Home Antibody All anti-DCLK2 antibodies
Also for DCLK2 (NM_001040260)
|DCLK2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DCLK2.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens doublecortin-like kinase 2 (DCLK2), transcript variant 1|
|CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2|
Entrez Gene 166614 Human
Entrez Gene 70762 Mouse
Entrez Gene 310698 Rat
|DCLK2 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK2 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.|
|Protein KinaseDruggable Genome |
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Western blot analysis of DCLK2 in rat brain tissue lysate with DCLK2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of DLCK2 in rat brain tissue with DLCK2 antibody at 5 ug/mL.