Home Antibody All anti-DAXX antibodies
Also for DAXX (NM_001141969)
|Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human Daxx.|
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens death-domain associated protein (DAXX), transcript variant 1|
|BING2; DAP6; EAP1|
Entrez Gene 1616 Human
Entrez Gene 13163 Mouse
|Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayAmyotrophic lateral sclerosis (ALS)|
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Western blot analysis of Daxx in 293 total cell lysate with Dax antibody at 1 mg/mL.
Immunocytochemistry of DAXX in HeLa cells with DAXX antibody at 10 ug/mL.