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Anti-DAND5 TRUEMAB Antibody clone 2H3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA503555
  • DAND5 mouse monoclonal antibody,clone 2H3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC407380) , 20ug
100ul 379 In Stock
CF503555
  • Carrier-free (BSA/glycerol-free) DAND5 mouse monoclonal antibody,clone 2H3
100ug $450 3-4 weeks
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WB(1)
IHC(3)
FC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli.
Clone Nameclone 2H3 IsotypeIgG1
Species ReactivityHuman Concentration1.04 mg/ml
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB 1:500~2000, IHC 1:150, FLOW 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens DAN domain family member 5, BMP antagonist (DAND5)
Alternative NameCER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1
Database LinkNP_689867
FunctionThis gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq].
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DAND5 (RC221703, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DAND5.
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503555)
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503555)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503555)
FC Image
HEK293T cells transfected with either RC221703 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-DAND5 antibody(TA503555), and then analyzed by flow cytometry.

 

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