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Home Antibody All anti-DAND5 antibodies

Anti-DAND5 TRUEMAB Antibody Clone OTI2H3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA503555 DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3) 100ul $379 In Stock
LC407380 DAND5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF503555 Carrier-free (BSA/glycerol-free) DAND5 mouse monoclonal antibody, clone OTI2H3 (formerly 2H3) 100ug $450 3-4 weeks
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WB(2)
IHC(3)
FC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli.
Clone NameClone OTI2H3 IsotypeIgG1
Species ReactivityHuman Concentration1.04 mg/ml
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB 1:500~2000, IHC 1:150, FLOW 1:100,
Predicted MW Explanation 18 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens DAN domain family member 5, BMP antagonist (DAND5)
Alternative NameCER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1
Database LinkNP_689867
Entrez Gene 199699 Human
FunctionThis gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq].
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DAND5 (RC221703, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DAND5.
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Western blot analysis of extracts (10ug) from 1 cell line by using anti-DAND5 monoclonal antibody. (1:200)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503555)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503555)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-DAND5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503555)
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HEK293T cells transfected with either RC221703 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-DAND5 antibody(TA503555), and then analyzed by flow cytometry.
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