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Home Antibody All anti-DACT3 antibodies

Anti-DACT3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306672
  • Rabbit Polyclonal Dact3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403420) , 20ug
100ug $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenDact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens dishevelled-binding antagonist of beta-catenin 3 (DACT3)
Alternative NameDAPPER3; RRR1
Database LinkNP_659493
FunctionThe Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 µg/ml.

 

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