Home Antibody All anti-Ccr2 antibodies
Also for Ccr2 (NM_001123041)
|Synthetic peptide surrounding to amino acid 353 of rat CCR2|
|Human, mouse, rat
|100 µg (0.5 mg/ml) affinity purified rabbit anti-CCR2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant A|
|CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R|
|Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.|
Cytokine-cytokine receptor interaction
Signaling by GPCR
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Western blot analysis of CCR2 expression in lysate from rat kidney (Lane 1), 3T3 cells (Lane 2) and Jurkat cells (Lane 3).