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Anti-CYCS Antibody EP1326Y
Also for CYCS (NM_018947)
|A synthetic peptide corresponding to residues near the N-terminus of human Cytochrome C was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:250; IHC: 1: 100; ICC: 1:50; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens cytochrome c, somatic (CYCS)|
|CYC; HCS; THC4|
Entrez Gene 54205 Human
Entrez Gene 13063 Mouse
Entrez Gene 25309 Rat
|Cytochrome c is located in the mitochondria of all aerobic cells and is involved in the electron transport system that functions in oxidative phosphorylation. It accepts electrons from cytochrome b and transfers them to cytochrome oxidase. In the process, the iron of the heme group, which is identical to that of hemoglobin and myoglobin, shifts from the ferrous to the ferric state (1). Recent progress in studies on apoptosis has revealed that cytochrome c is a pro-apoptotic factor. It is released from its places on the outer surface of the inner mitochondrial membrane at early steps of apoptosis and, combining with some cytosolic proteins, activates conversion of the latent apoptosis-promoting protease pro-caspase-9 to its active form. Cytochrome c release can be initiated by the pro-apoptotic protein Bax. This process is blocked by the anti-apoptotic proteins Bcl-2 and Bcl-xL (2). Also, differences in amino acid composition of cytochrome c have also been used as markers of biochemical evolution. |
|Druggable Genome p53 signaling pathwayApoptosisAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseMore Pathways >> |
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Western blot - Cytochrome C antibody [EP1326Y]; Anti-Cytochrome C antibody [EP1326Y] at 1/500 dilution + HeLa cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/1000 dilution.Observed band size : 14 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytochrome C antibody [EP1326Y]; TA301005, at a 1/100 dilution, staining human Cytochrome C in heart muscle by Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytochrome C antibody [EP1326Y]; TA301005, at a 1/100 dilution, staining human Cytochrome C in kidney by Immunohistochemistry Formalin/PFA-fixed paraffin-embedded tissue.