Home Antibody All anti-CHUK antibodies
Also for CHUK (NM_001278)
|IKK alpha antibody was raised against a peptide corresponding to amino acids 699 to 715 of human IKK alpha, which differs from corresponding murine sequence by one amino acid .|
||ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens conserved helix-loop-helix ubiquitous kinase (CHUK)|
|IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16|
|Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and bacteria product LPS. NF-kappaB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKΒ). IKKalpha and IKKb interact with each other and both are essential for the NF-kappaB activation. IKKalpha specifically phosphorylates IkappaB-Α.IKKalpha is expressed in a variety of human tissues.|
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot analysis of IKK alpha in HeLa whole cell lysate with IKK alpha antibody at 1:500 dilution.
Immunofluorescence of IKKa in HeLa cells with IKKa antibody at 2 ug/mL.