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Home Antibody All anti-CHUK antibodies

Anti-CHUK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305976
  • Rabbit Polyclonal IKK alpha Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400513) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenIKK alpha antibody was raised against a peptide corresponding to amino acids 716 to 734 of human IKK alpha, which differs from corresponding murine sequence by four amino acids .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens conserved helix-loop-helix ubiquitous kinase (CHUK)
Alternative NameIKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
Database LinkNP_001269
FunctionNuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IΚB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta). IKKa and IKKbeta interact with each other and both are essential for the NF-kappaB activation. IKKalpha specifically phosphorylates IkB-alpha. IKKalpha is expressed in variety of human tissues.
Related Pathway
Apoptosis
MAPK signaling pathway
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of IKK alpha in HeLa whole cell lysate with IKK alpha antibody at 1:1000 dilution.
IF Image
Immunocytochemistry of IKK alpha in Jurkat cells with IKK alpha antibody at 1ug/mL.

 

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