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Home Antibody All anti-CFLAR antibodies

Anti-CFLAR Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305963
  • Rabbit Polyclonal FLIP Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC426693) , 20ug
100ug 325 In Stock
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WB(1)
IF(1)
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Also for CFLAR (NM_001127183)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFLIP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human FLIPaFLIPl form.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 2
Alternative Namec-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
Database LinkNP_001120655
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively (8).
Related Pathway
Apoptosis

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WB Image
Western blot analysis of FLIP in HeLa (H), Jurkat (J), and K562 (K) whole cell lysate with FLIP antibody at 1:1000 dilution.
IF Image
Immunocytochemistry of FLIP in Jurkat cells with FLIP antibody at 10 ug/mL.

 

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