Anti-CFLAR Antibody,

Also for CFLAR (NM_001127183)

OriGene Data

Immunogen	FLIP antibody was raised against a peptide corresponding to amino acids near the amino terminus of human FLIP The sequence is identical in all FLIP splice variants.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Guaranteed Application *	WB, IF	Suggested Dilutions	ELISA, WB: 1 - 2 ug/ml, IHC, IF: 20 ug/ml, FC
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 2
Alternative Name	c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
Database Link	NP_001120655
Function	Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively.
Related Pathway	Apoptosis

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WB Image

Western blot analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2 ug/mL.

IF Image

Immunocytochemistry of FLIP in HeLa cells with FLIP antibody at 5 ug/mL.

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OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

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FITC
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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-CFLAR Antibody

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data