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Anti-CDKN1A Antibody EPR3993
Also for CDKN1A (NM_078467)
|A synthetic peptide corresponding to residues in human p21 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2|
|CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1|
|Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1, p21, CDKN1A, WAF1) plays a critical role in the cellular response to DNA damage, and its overexpression results in cell cycle arrest (1). p21 binds to and inhibits CDK activity, preventing phosphorylation of critical CDK substrates and blocking cell cycle progression. p21 is suggested to possibly be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage (2). Endogenous cellular p21 is shown to be completely acetylated at its amino terminus and is therefore not a substrate for N-ubiquitylation (3).|
Senescence and Autophagy
TGF Beta Signaling Pathway
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Western blot - p21 antibody [EPR3993]; All lanes : Anti-p21 [EPR3993] antibody at 1/1000 dilution.Lane 1 : HUVEC cell lysate .Lane 2 : U87MG cell lysate.Lane 3 : C6 cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 18 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p21 antibody [EPR3993]; TA307018, at 1/250 dilution, staining p21 in paraffin-embedded Human colon tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p21 antibody [EPR3993]; TA307018, at 1/250 dilution, staining p21 in paraffin-embedded Human stomach adenocarcinoma tissue by Immunohistochemistry.