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Home Antibody All anti-CDKN1A antibodies

Anti-CDKN1A Antibody EPR3993

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307018
  • Rabbit monoclonal antibody against p21(clone EPR3993)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC409213) , 20ug
100ul 325 In Stock
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WB(1)
IHC(2)
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Also for CDKN1A (NM_078467)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p21 was used as an immunogen.
Clone NameEPR3993 IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2
Alternative NameCAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Database LinkNP_510867
FunctionCyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1, p21, CDKN1A, WAF1) plays a critical role in the cellular response to DNA damage, and its overexpression results in cell cycle arrest (1). p21 binds to and inhibits CDK activity, preventing phosphorylation of critical CDK substrates and blocking cell cycle progression. p21 is suggested to possibly be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage (2). Endogenous cellular p21 is shown to be completely acetylated at its amino terminus and is therefore not a substrate for N-ubiquitylation (3).
Related Pathway
Adipogenesis
Cell cycle
Senescence and Autophagy
TGF Beta Signaling Pathway

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WB Image
Western blot - p21 antibody [EPR3993]; All lanes : Anti-p21 [EPR3993] antibody at 1/1000 dilution.Lane 1 : HUVEC cell lysate .Lane 2 : U87MG cell lysate.Lane 3 : C6 cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 18 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p21 antibody [EPR3993]; TA307018, at 1/250 dilution, staining p21 in paraffin-embedded Human colon tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p21 antibody [EPR3993]; TA307018, at 1/250 dilution, staining p21 in paraffin-embedded Human stomach adenocarcinoma tissue by Immunohistochemistry.

 

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