Homo sapiens cadherin 3, type 1, P-cadherin (placental) (CDH3)
CDHP; HJMD; PCAD
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CDH3.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody is purified by peptide affinity purification. (Protein A or G Sepharose)
Guaranteed Application *
WB: 1:50~100; IHC: 1: 10~50; ELISA: 1: 1,000;
CDH3 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in the gene encoding CDH3 have been associated with congential hypotrichosis with juvenile macular dystrophy.
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Western blot analysis of anti-CDH3 Antibody (C-term) in K562 cell line lysates (35ug/lane). CDH3(arrow) was detected using the purified Pab (1:60 dilution). Western blot analysis of CDH3 (arrow) using rabbit polyclonal CDH3 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH3 gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with CDH3 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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