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Also for CDC2 (NM_001786)
|This CDK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human CDK1.|
|Human (Predicted: Mouse, Rat, Bovine, Chicken, Drosophila, Xenopus)
||WB: 1:1000, IHC: 1:10~50
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|This antibody is purified through a protein A column, followed by peptide affinity purification.
|Homo sapiens cyclin-dependent kinase 1 (CDK1), transcript variant 1|
|CDC2; CDC28A; P34CDC2|
Entrez Gene 983 Human
Entrez Gene 12534 Mouse
Entrez Gene 54237 Rat
|CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.|
Hedgehog signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis of CDK1(arrow) using rabbit polyclonal CDK1 Antibody (T14) (Cat.#TA302013). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDK1 gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDK1 Antibody (T14) (Cat.#TA302013), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.