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Anti-CD40 Antibody HM40-3
Also for CD40 (NM_011611)
||0.5-1mg/ml (lot dependent)
||Flow, IHC, Functional Assay
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Mus musculus CD40 antigen (Cd40), transcript variant 1|
|AI326936; Bp50; GP39; HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP|
Entrez Gene 21939 Mouse
Entrez Gene 171369 Rat
|The HM40-3 monoclonal antibody reacts with mouse and rat CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.|
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Staining of BALB/c splenocytes with 0.5 ug Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.5 ug Anti-Mouse/Rat CD40 Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC . Total viable cells were used for analysis.