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Home Antibody All anti-CD40 antibodies

Anti-CD40 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA318864
  • Rabbit polyclonal anti-CD40 antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to residues surrounding amino acids 261 of human CD40
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat, monkey, pig Concentration0.2 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4ug/ml
Buffer100 µg (0.2 mg/ml) immunoaffinity purified rabbit anti-CD40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2
Alternative NameBp50; CDW40; p50; TNFRSF5
Database LinkNP_690593
Entrez Gene 958 Human
Entrez Gene 21939 Mouse
Entrez Gene 171369 Rat
Entrez Gene 707749 Monkey
FunctionCD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionCell adhesion molecules (CAMs)Toll-like receptor signaling pathwayAsthmaAutoimmune thyroid diseaseSystemic lupus erythematosusMore Pathways >>

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WB Image
Western blot analysis of CD40 expression in rat kidney tissue lysate.

 

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