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Anti-CD3G Antibody EPR4517
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Also for CD3G (NM_000073)
|A synthetic peptide corresponding to residues at the C-terminus of human CD3 gamma was used as an immunogen.|
||ICC: 1:500 - 1,000, IHC: 1:250 - 500, IP: 1:10 - 100, WB: 1:10,000 - 50,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens CD3g molecule, gamma (CD3-TCR complex) (CD3G)|
|CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta (3). CD3 forms complex with the T cell antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C (1,2). Defects in this protein are associated with T cell immunodeficiency (4).|
Hematopoietic cell lineage
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Western blot analysis on (A) Jurkat and (B) mouse thymus lysates using anti-CD3 gamma RabMAb .
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD3 gamma RabMAb .