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Home Antibody All anti-CD3G antibodies

Anti-CD3G Antibody EPR4517

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307757 Rabbit monoclonal antibody against CD3 gamma(clone EPR4517) 100ul $325 In Stock
LC400019 CD3G HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(5)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human CD3 gamma was used as an immunogen.
Clone NameEPR4517 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:500 - 1:1000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
Purification Protein A purified
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens CD3g molecule, gamma (CD3-TCR complex) (CD3G)
Alternative NameCD3-GAMMA; IMD17; T3G
Database LinkNP_000064
Entrez Gene 917 Human
Entrez Gene 12502 Mouse
FunctionCD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta (3). CD3 forms complex with the T cell antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C (1,2). Defects in this protein are associated with T cell immunodeficiency (4).
Related PathwayTransmembraneDruggable Genome Hematopoietic cell lineageT cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-CD3G antibody [EPR4517]; All lanes : Anti-CD3G antibody [EPR4517] at 1/10000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Mouse thymus lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 20 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD3G antibody [EPR4517]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labelling CD3G with TA307757 at 1/250 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD3G antibody [EPR4517]; Immunohistochemical analysis of paraffin-embedded Mouse spleen tissue labelling CD3G with TA307757 at 1/250 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD3G antibody [EPR4517](TA307757); Immunohistochemical analysis of paraffin embedded Human Skeletal muscle tissue using TA307757 showing -ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD3G antibody [EPR4517](TA307757); Immunohistochemical analysis of paraffin embedded normal Human brain tissue using TA307757 showing -ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD3G antibody [EPR4517](TA307757); Immunohistochemical analysis of paraffin embedded normal Human colon (lymphocytes) tissue using TA307757 showing +ve staining.
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