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Anti-CCM2 TRUEMAB Antibody clone 2E4
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for CCM2 (NM_031443)
|Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.|
|WB, IHC, IF
||WB 1:2000, IHC 1:150, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens cerebral cavernous malformation 2 (CCM2), transcript variant 2|
|C7orf22; OSM; PP10187|
Entrez Gene 83605 Human
|This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CCM2 (RC201418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CCM2.
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503416)
Anti-CCM2 mouse monoclonal antibody (TA503416) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418).