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Home Antibody All anti-CBL antibodies

Anti-CBL PHOSPHO Antibody EPR2227

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310245
  • Rabbit Monoclonal antibody against Cbl, pY674 (CBL) (Phospho-specific)
100ul 325 3-7 Days
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FC(1)
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Also for CBL (NM_005188)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 674 of human Cbl were used as an immunogen. This antibody detects Cbl phosphorylated on tyrosine 674.
Clone NameEPR2227 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *FC Suggested DilutionsWB: 1:1000 - 2000;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Alternative NameC-CBL; CBL2; FRA11B; NSLL; RNF55
Database LinkNP_005179
Entrez Gene 867 Human
Functionc-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). It has been demonstrated that certain tyrosines are the major phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation. Cbl also enhances migration of v-Abl-transformed NIH 3T3 fibroblasts. This effect of Cbl depends on its tyrosine phosphorylation, which is required for binding of PI-3' kinase to c-Cbl (5)
Related PathwayTranscription FactorsDruggable Genome ErbB signaling pathwayUbiquitin mediated proteolysisEndocytosisJak-STAT signaling pathwayT cell receptor signaling pathwayInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

FC Image
Flow cytometric analysis of permeabilized Jurkat cells, un-treated (green) or pervanadate treated (red) using TA310245 at a 1/20 dilution, and pervanadate-treated Jurkat cells using the same antibody pre-incubated with phospho-CBL peptide (blue) or non-phospho-CBL peptide (orange).

 

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