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Home Antibody All anti-CBL antibodies

Anti-CBL PHOSPHO Antibody EP2225Y

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310244
  • Rabbit Monoclonal antibody against Cbl, pY700 (CBL) (Phospho-specific)
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 700 were used as an immunogen. This antibody detects Cbl phosphorylated on tyrosine 700.
Clone NameEP2225Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 ; IP: 1:30;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Alternative NameC-CBL; CBL2; FRA11B; NSLL; RNF55
Database LinkNP_005179
Entrez Gene 867 Human
Functionc-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). It has been demonstrated that tyrosines 700, 731, and 774 are the major tyrosine phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation (5).
Related PathwayTranscription FactorsDruggable Genome ErbB signaling pathwayUbiquitin mediated proteolysisEndocytosisJak-STAT signaling pathwayT cell receptor signaling pathwayInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

All lanes : Anti-CBL (phospho Y700) antibody [EP2225Y] (TA310244) at 1/10000 dilution. Lane 1 : Jurkat cell lysate, untreated; Lane 2 : Jurkat cell lysate, treated with pervanadate. Lysates/proteins at 10 ug per lane. Secondary: HRP labelled goat anti-rabbit at 1/2000 dilution.
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