Home Antibody All anti-CASP9 antibodies
Also for CASP9 (NM_001229)
|Caspase-9 antibody was raised against a peptide corresponding to amino acids 299 to 318 of human caspase-9 .|
||ELISA, WB: 1:1000, ICC: 2 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha|
|APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56|
Entrez Gene 842 Human
|Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (1-3). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (3). Caspase-9 is also activated by granzyme B and CPP32 (1,2). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD (4). Caspase-9 is expressed in a variety of human tissues (1,2).|
|ProteaseStem cell - PluripotencyDruggable Genome p53 signaling pathwayApoptosisVEGF signaling pathwayAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)More Pathways >> |
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Western blot analysis of caspase-9 in HeLa whole cell lysate with Caspase-9 antibody at 1:1000 dilution
Immunocytochemistry staining of K562 cells using Caspase-9 antibody at 2 ug/mL.