Home Antibody All anti-CASP7 antibodies
Also for CASP7 (NM_033339)
|Full-length recombinant human Caspase 7 protein|
|human, rat, mouse
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500-1: 1000
|Ascitic fluid and 0.1% sodium azide|
|Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant c|
|CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3|
|Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.|
MAPK signaling pathway
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY CASP7 (RC202059) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CASP7.