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Home Antibody All anti-CASP4 antibodies

Anti-CASP4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306196 Rabbit Polyclonal Caspase-4 Antibody 100ug $325 3-7 Days
LC400489 CASP4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for CASP4 (NM_001225)
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OriGene Data

ImmunogenCaspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha
Alternative NameICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX
Database LinkNP_001216
Entrez Gene 837 Human
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of caspase-4 in human spleen cells with caspase-4 antibody at (A) 1 and (B) 2 ug/ml.

IHC Image
Immunohistochemical staining of human spleen tissue using caspase-4 antibody at 2 ug/ml.

IF Image
Immunofluorescence of Caspase-4 in A20 cells with Caspase-4 antibody at 10 ug/mL.


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