Home Antibody All anti-CARD10 antibodies
Also for CARD10 (NM_014550)
|CARD10 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human CARD10.|
||ELISA, WB: 5 - 10 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Homo sapiens caspase recruitment domain family, member 10 (CARD10)|
Entrez Gene 29775 Human
Entrez Gene 105844 Mouse
|Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10 (1). This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (2). CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kappaB (1,3). CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IkappaK complex (4), demonstrating its importance in the regulation of NF-kappaB transcription factor activation.|
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Western blot analysis of CARD10 expression in EL4 cell lysate with CARD10 antibody at (A) 5 and (B) 10 ug /ml.
Immunocytochemistry of CARD10 in EL4 cells with CARD10 antibody at 10 ug/mL.