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Home Antibody All anti-CAMK2B antibodies

Anti-CAMK2B Antibody EPR6685(B)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310230
  • Rabbit Monoclonal antibody against CaMKII (CAMK2B)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420062) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
FC(1)
Assay(1)
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Also for CAMK2B (NM_001220)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CaMKII was used as an immunogen.
Clone NameEPR6685(B) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant 1
Alternative NameCAM2; CAMK2; CAMKB
Database LinkNP_001211
Entrez Gene 816 Human
Entrez Gene 12323 Mouse
Entrez Gene 24245 Rat
FunctionCalcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).
Related PathwayProtein KinaseDruggable Genome ErbB signaling pathwayCalcium signaling pathwayOocyte meiosisWnt signaling pathwayLong-term potentiationNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CaMKII antibody [EPR6685(B)]; All lanes : Anti-CaMKII antibody [EPR6685(B)] at 1/1000 dilution.Lane 1 : Human pancreas lysate.Lane 2 : Human fetal kidney lysate.Lane 3 : HeLa lysate.Lane 4 : Jurkat lysate.Lane 5 : SH SY5Y lysate.Lane 6 : BxPC3 lysate.Lane 7 : C6 lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51-73 kDa.
Assay Image
Other-Anti-CaMKII antibody [EPR6685(B)](TA310230); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-CaMKII antibody [EPR6685(B)]; TA310230 at 1/10 dilution staining CaMKII in permeabilized C6 cells by Flow cytometry (red) compared with a rabbit IgG negative control (green).

 

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