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[anti-HA]
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[Akt3]
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[LA]
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[JAK2]
Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1
Synonyms:
CAMKA
Immunogen
A phospho specific peptide corresponding to residues surrounding Threonine 286 of human CaMKII was used as an immunogen. This antibody only detects CaMKII phosphorylated at Threonine 286.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. It is a ubiquitous serine/threonine protein kinase which is abundant in brain as a major PSD constituent. This enzyme is composed of distinct but related subunits (alpha, beta, gamma, and delta) (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2). The most important autophosphorylation site is Threonine 286, which resides in the vicinity of the autoinhibitory domain (3).
Related Pathway
EGFR1 Signaling Pathway
Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis on rat brain lysates using anti-Phospho-CaMKII (pT286) RabMAb. Cells were either (A) untreated (B) treated with Lambda Phosphatase.
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