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Home Antibody All anti-Bcan antibodies

Anti-Bcan Antibody S294A-6


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326514 Mouse Monoclonal Anti-Brevican Antibody 100µg $325 3-7 Days
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OriGene Data

ImmunogenFusion protein amino acids 219-655 of rat Brevican,
Clone NameS294A-6 IsotypeIgG2B
Species ReactivityRat, Mouse Concentration1mg/mL
Guaranteed Application * Suggested DilutionsWB: 1:1000
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~140kDa (and smaller due to proteolytic cleavage)

Reference Data

Target NameRattus norvegicus brevican (Bcan), transcript variant 1
Alternative NameALPBRE; BEHAB
Database LinkNP_001028837
Entrez Gene 12032 Mouse
Entrez Gene 25393 Rat
FunctionBrevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adultbrain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bearchondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD Nterminal fragment is formed that contains the unique Cterminal epitope EAMESE.
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