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Home Antibody All anti-BTRC antibodies

Anti-BTRC Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA324231 Anti-BTRC Rabbit Polyclonal Antibody 100ul 325
2-3 Weeks
LC403255 BTRC HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenFusion protein corresponding to a region derived from 50-340 amino acids of human beta-transducin repeat containing E3 ubiquitin protein ligase
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration0.97mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-2000
Predicted MW Explanation 69kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 3
Alternative NameBETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Database LinkNP_001243785
Entrez Gene 8945 Human
Entrez Gene 12234 Mouse
Entrez Gene 361765 Rat
Functionß-transducin repeat-containing protein (ß-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination. ß-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, I?Ba, ß-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation. Research studies have shown that inhibition of ß-TrCP expression has a demonstrated benefit in the treatment of prostate cancer.
Related PathwayDruggable Genome Oocyte meiosisUbiquitin mediated proteolysisWnt signaling pathwayHedgehog signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 69 kDa . Positive control: Kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)


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