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[anti-HA]
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[Akt3]
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[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK)
Synonyms:
AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Immunogen
A phospho specific peptide corresponding to residues surrounding tyrosine 223 of human BTK was used as an immunogen. This antibody detects BTK phosphorylated on tyrosine 223.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq].
Related Pathway
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Western blot analysis on Ramos cell lysates using anti-Phospho-BTK (pY223) RabMAb (TA303406), 1:500,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
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